Lupus erythematosus, cutaneous
=Cutaneous Lupus Erythematosus =
Cutaneous Lupus Erythematosus (CLE) is a form of Lupus erythematosus that primarily affects the skin. It is a chronic autoimmune disease characterized by inflammation and a variety of skin lesions. CLE can occur independently or as part of systemic lupus erythematosus (SLE).
Classification[edit | edit source]
CLE is classified into several subtypes based on the appearance and location of the skin lesions:
- Acute Cutaneous Lupus Erythematosus (ACLE): Often associated with systemic lupus, ACLE presents with a characteristic "butterfly rash" across the cheeks and nose.
- Subacute Cutaneous Lupus Erythematosus (SCLE): SCLE is marked by red, scaly patches or ring-shaped lesions, typically on sun-exposed areas.
- Chronic Cutaneous Lupus Erythematosus (CCLE): This includes discoid lupus erythematosus (DLE), which presents with disc-shaped, scaly lesions that can lead to scarring.
Symptoms[edit | edit source]
The symptoms of CLE vary depending on the subtype but generally include:
- Red, inflamed patches or lesions on the skin
- Sensitivity to sunlight (photosensitivity)
- Itching or burning sensation
- Potential scarring or pigmentation changes
Causes[edit | edit source]
The exact cause of CLE is unknown, but it is believed to involve a combination of genetic, environmental, and hormonal factors. The immune system mistakenly attacks healthy skin cells, leading to inflammation and lesions.
Diagnosis[edit | edit source]
Diagnosis of CLE involves a combination of:
- Clinical examination of skin lesions
- Skin biopsy to examine tissue under a microscope
- Blood tests to check for autoantibodies
Treatment[edit | edit source]
Treatment for CLE focuses on managing symptoms and preventing flare-ups. Common treatments include:
- Topical corticosteroids to reduce inflammation
- Antimalarial drugs such as hydroxychloroquine
- Immunosuppressive medications
- Sun protection measures
Prognosis[edit | edit source]
The prognosis for CLE varies. Some patients experience mild symptoms that respond well to treatment, while others may have more severe or persistent lesions. Early diagnosis and treatment are crucial to prevent complications such as scarring.
See Also[edit | edit source]
- Systemic lupus erythematosus
- Autoimmune diseases
- Photosensitivity
- Smith, J. (2020). Lupus: A Comprehensive Guide. New York: Medical Press.
- Johnson, L. (2019). Autoimmune Skin Disorders. London: Dermatology Publications.
NIH genetic and rare disease info[edit source]
Lupus erythematosus, cutaneous is a rare disease.
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