Ceftizoxime sodium

Ceftizoxime Sodium is a cephalosporin antibiotic used in the treatment of various bacterial infections. It is a third-generation cephalosporin that is primarily used against gram-negative bacteria. Ceftizoxime Sodium is also effective against some gram-positive bacteria.

Pharmacology

Ceftizoxime Sodium works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. This results in cell lysis due to the action of bacterial cell wall autolytic enzymes.

Medical Uses

Ceftizoxime Sodium is used to treat a variety of bacterial infections, including those caused by Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. It is also used in the treatment of infections caused by Staphylococcus aureus and Streptococcus pneumoniae.

Side Effects

Common side effects of Ceftizoxime Sodium include nausea, vomiting, diarrhea, and allergic reactions. Serious side effects may include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis.

Precautions

Patients with a history of allergic reactions to penicillin or other cephalosporins should use Ceftizoxime Sodium with caution. It should also be used with caution in patients with renal impairment, as dosage adjustment may be necessary.

Interactions

Ceftizoxime Sodium may interact with other medications, including aminoglycosides, loop diuretics, and other nephrotoxic drugs. These interactions can increase the risk of kidney damage.

See Also

• Cephalosporin
• Antibiotics
• Bacterial Infections