CCR8 (gene)
CCR8 (Chemokine (C-C motif) receptor 8) is a gene that encodes a member of the G protein-coupled receptor family. This gene is located on the chromosome 3 in humans. The protein encoded by this gene is a receptor for the C-C type chemokines CCL1, CCL3, CCL4, CCL5, CCL8, CCL14, and CCL16. The function of this gene has been linked to the regulation of immune system responses.
Function[edit | edit source]
CCR8 is a receptor for the chemokine CCL1. It is expressed in T cells, particularly in T helper 2 (Th2) cells. The interaction between CCL1 and CCR8 has been shown to play a role in the recruitment of Th2 cells to sites of inflammation. This gene may also play a role in the pathogenesis of allergic reactions and asthma.
Clinical significance[edit | edit source]
Alterations in the expression of CCR8 have been associated with various diseases. For example, increased expression of CCR8 has been observed in HIV-infected individuals, suggesting a role for this gene in the progression of HIV infection. Additionally, mutations in this gene have been associated with a susceptibility to asthma and other allergic diseases.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- CCR8 at the US National Library of Medicine Medical Subject Headings (MeSH)
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