CCR8 (gene)

CCR8 (Chemokine (C-C motif) receptor 8) is a gene that encodes a member of the G protein-coupled receptor family. This gene is located on the chromosome 3 in humans. The protein encoded by this gene is a receptor for the C-C type chemokines CCL1, CCL3, CCL4, CCL5, CCL8, CCL14, and CCL16. The function of this gene has been linked to the regulation of immune system responses.

Function

CCR8 is a receptor for the chemokine CCL1. It is expressed in T cells, particularly in T helper 2 (Th2) cells. The interaction between CCL1 and CCR8 has been shown to play a role in the recruitment of Th2 cells to sites of inflammation. This gene may also play a role in the pathogenesis of allergic reactions and asthma.

Clinical significance

Alterations in the expression of CCR8 have been associated with various diseases. For example, increased expression of CCR8 has been observed in HIV-infected individuals, suggesting a role for this gene in the progression of HIV infection. Additionally, mutations in this gene have been associated with a susceptibility to asthma and other allergic diseases.

See also

• Chemokine receptor
• Chemokine
• G protein-coupled receptor
• T helper cell

External links

• CCR8 at the US National Library of Medicine Medical Subject Headings (MeSH)