CXCR5
CXCR5 is a G protein-coupled receptor that in humans is encoded by the CXCR5 gene. It is also known as Burkitt lymphoma receptor 1 (BLR1), and is a member of the CXC chemokine receptor family.
Function[edit | edit source]
CXCR5 is a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and T cells, and is known to control the migration of these cells in lymphoid tissues. The receptor is activated by a chemokine known as CXCL13 (also known as BLC or BCA-1), which is produced in the lymphoid follicles of the spleen, lymph nodes, and Peyer's patches.
Clinical significance[edit | edit source]
Alterations in the CXCR5 gene have been associated with various diseases. For instance, mutations in this gene have been linked to Burkitt's lymphoma, a type of non-Hodgkin lymphoma. Additionally, the CXCR5-CXCL13 axis is thought to play a role in the pathogenesis of autoimmune diseases such as Multiple sclerosis and Rheumatoid arthritis.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- CXCR5 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
