Interleukin 8 receptor, alpha

Interleukin 8 receptor, alpha (also known as IL8RA) is a protein that in humans is encoded by the IL8RA gene. This receptor is a member of the G protein-coupled receptor family, and is an integral part of the immune system.

Function

The IL8RA protein is a receptor for Interleukin 8 (IL8). It shares with IL8RB a common beta subunit necessary for receptor activation, which is a major mediator of the inflammatory response. This receptor/IL8 complex regulates neutrophil migration and degranulation which is necessary for direct target cell lysis. IL8RA is also involved in angiogenesis, inflammation, wound healing, and cancer metastasis.

Clinical significance

Alterations in the function of IL8RA have been associated with susceptibility to melanoma and other cancers. It is also implicated in the pathogenesis of several inflammatory diseases such as rheumatoid arthritis and asthma.

See also

• Interleukin 8
• Interleukin 8 receptor, beta
• G protein-coupled receptor
• Neutrophil
• Angiogenesis

External links

• IL8RA at the National Center for Biotechnology Information

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