CCRL1

CCRL1 (Chemokine (C-C motif) receptor-like 1) is a protein that in humans is encoded by the CCRL1 gene. This protein is a member of the G protein-coupled receptor family, which are integral membrane proteins that respond to various stimuli like light, hormones, and neurotransmitters.

Structure of the CCRL1 protein. Image from Wikimedia Commons.

Function

The CCRL1 protein is a receptor for chemokines, a family of small molecules that regulate cell trafficking of various types of leukocytes. The CCRL1 protein is closely related to another chemokine receptor, CCR3, and has been shown to specifically bind to the chemokine CCL19.

Clinical significance

Alterations in the CCRL1 gene have been associated with various diseases, including asthma, rheumatoid arthritis, and cancer. In particular, overexpression of CCRL1 has been observed in several types of cancer, suggesting a potential role in tumor progression.

Research

Research on CCRL1 is ongoing, with studies investigating its role in immune response, inflammation, and cancer progression. Understanding the function of CCRL1 could potentially lead to new therapeutic strategies for these conditions.

See also

• Chemokine receptor
• G protein-coupled receptor
• Chemokine
• Leukocyte
• Asthma
• Rheumatoid arthritis
• Cancer