CCR1

From WikiMD's Food, Medicine & Wellness Encyclopedia

CCR1 is a gene that encodes the Chemokine receptor CCR1 in humans. It is also known as CD191 (Cluster of Differentiation 191).

Function[edit | edit source]

CCR1 is a receptor for CCL3, CCL5, CCL7, and CCL14. The gene is located on the third chromosome (3p21) in humans. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is a receptor for various CC chemokines, and it transduces a signal by increasing the intracellular calcium ions level.

Clinical significance[edit | edit source]

CCR1 has been implicated in rheumatoid arthritis, multiple sclerosis, and as a potential therapeutic target in HIV infection.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]

CCR1 Resources
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Contributors: Prab R. Tumpati, MD