CCR1
CCR1 is a gene that encodes the Chemokine receptor CCR1 in humans. It is also known as CD191 (Cluster of Differentiation 191).
Function[edit | edit source]
CCR1 is a receptor for CCL3, CCL5, CCL7, and CCL14. The gene is located on the third chromosome (3p21) in humans. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is a receptor for various CC chemokines, and it transduces a signal by increasing the intracellular calcium ions level.
Clinical significance[edit | edit source]
CCR1 has been implicated in rheumatoid arthritis, multiple sclerosis, and as a potential therapeutic target in HIV infection.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- CCR1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
