IL17RA

IL17RA is a human gene that encodes for the Interleukin 17 receptor A. This receptor is a part of the interleukin-17 receptor family, a group of receptors that play a crucial role in inflammatory responses and in the development of certain diseases such as rheumatoid arthritis and psoriasis.

Function

The IL17RA gene is responsible for the production of the IL17RA protein, which is a part of the cytokine receptor family. This protein is a receptor for interleukin 17A, interleukin 17F, and interleukin 25. It plays a vital role in mediating the inflammatory response, including the activation of the NF-kappa B pathway.

Clinical Significance

Mutations in the IL17RA gene have been associated with several diseases. For instance, a deficiency in IL17RA can lead to chronic mucocutaneous candidiasis, a condition characterized by persistent and recurrent infections of the skin, nails, and mucous membranes.

Furthermore, the IL17RA gene has been implicated in the pathogenesis of autoimmune diseases such as rheumatoid arthritis and psoriasis. Studies have shown that blocking the IL17RA receptor can help reduce inflammation and disease activity in these conditions.

Research

Research into the IL17RA gene and its associated protein continues to be a significant area of interest in the field of immunology. Understanding the role of this gene in the immune response and disease development may lead to the development of new therapeutic strategies for a variety of conditions.

File:IL17RA gene location.png

Location of the IL17RA gene on chromosome 22.

See Also

• Interleukin 17
• Interleukin 17 receptor
• Cytokine
• NF-kappa B
• Chronic mucocutaneous candidiasis
• Rheumatoid arthritis
• Psoriasis