Liposomal amphotericin B
<languages /><translate> A liposome-encapsulated formulation of the polyene antifungal antibiotic amphotericin B.
How is it produced?[edit | edit source]
It is produced by the bacterium Streptomyces nodosus with antifungal activity.
Mechanism of action[edit | edit source]
Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, and alters cell membrane integrity, resulting in leakage of intracellular components and cell rupture.
Oxidative damage[edit | edit source]
This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.
Benefits of liposomal amphotericin B[edit | edit source]
Compared to amphotericin B alone, liposomal delivery of amphotericin B allows for a greater drug concentration in target tissues while decreasing systemic side effects.
Synonym[edit | edit source]
Amphotericin B-lipid complex
US brand name[edit | edit source]
Abelcet AmBisome
Acronym[edit | edit source]
L-AMB </translate>
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Contributors: Prab R. Tumpati, MD
