Glyceollin I
Glyceollin I is a phytoalexin produced by the soybean plant (Glycine max) in response to stress or pathogen attack. It is one of the three main glyceollins, along with Glyceollin II and Glyceollin III, and is known for its various biological activities, including antioxidant, anti-inflammatory, and anticancer properties.
Biosynthesis[edit | edit source]
The biosynthesis of Glyceollin I involves the isoflavonoid pathway, which is a branch of the general phenylpropanoid pathway in plants. The process begins with the conversion of phenylalanine to cinnamic acid by the enzyme phenylalanine ammonia-lyase (PAL). This is followed by a series of enzymatic reactions involving cinnamate 4-hydroxylase (C4H), 4-coumarate:CoA ligase (4CL), chalcone synthase (CHS), chalcone isomerase (CHI), and isoflavone synthase (IFS), leading to the formation of the isoflavone daidzein. Daidzein is then converted to Glyceollin I through the action of glyceollin synthase.
Biological Activities[edit | edit source]
Glyceollin I has been shown to exhibit a range of biological activities. It has potent antioxidant activity, helping to neutralize harmful free radicals in the body. It also has anti-inflammatory properties, reducing the production of pro-inflammatory cytokines and inhibiting the activation of NF-kappa B, a key regulator of inflammation.
In addition, Glyceollin I has been found to have anticancer properties. It can inhibit the growth of various types of cancer cells, including breast cancer and prostate cancer cells, by inducing apoptosis (programmed cell death) and inhibiting angiogenesis (the formation of new blood vessels that feed tumors).
Research and Potential Applications[edit | edit source]
Due to its biological activities, Glyceollin I has been the subject of numerous research studies. It has potential applications in the prevention and treatment of various diseases, including cancer, cardiovascular disease, and neurodegenerative disease. However, more research is needed to fully understand its mechanisms of action and to determine its safety and efficacy in humans.
See Also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
