Fluclotizolam
Fluclotizolam is a thienotriazolodiazepine derivative which was first synthesized in 1979, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified in 2017.
Chemistry[edit | edit source]
Fluclotizolam is a thienotriazolodiazepine, which is a group of benzodiazepine analogs. The thienotriazolodiazepine core of fluclotizolam is a combination of a thiophene ring fused with a triazolodiazepine ring. This core structure is shared with a number of other benzodiazepine drugs, including etizolam and brotizolam.
Pharmacology[edit | edit source]
Like other benzodiazepines, fluclotizolam acts as a positive allosteric modulator of the GABA_A receptor, enhancing the effects of the neurotransmitter GABA. This results in sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant effects.
Effects[edit | edit source]
The effects of fluclotizolam are similar to other benzodiazepines, such as anxiolysis, disinhibition, lethargy, muscle relaxation, and euphoria. However, due to its potency, it also has a high potential for abuse and can cause severe physical dependence and withdrawal symptoms.
Legal Status[edit | edit source]
The legal status of fluclotizolam varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use.
See Also[edit | edit source]
Sedatives and Hypnotics[edit source]
- Herbals
- Chamomile (Matricaria recutita)
- Hops (Humulus lupulus)
- Lavender (Lavandula angustifolia)
- Passionflower (Passiflora incarnata)
- Valerian (Valeriana officinalis)
- Melatonin and its Analogues
Miscellaneous Agents
- Buspirone
- Chloral hydrate
- Doxepin
- Meprobamate
- Sodium Oxybate (Narcolepsy Agent)
- Suvorexant
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