Neomycin
(Redirected from Neo-Fradin)
Information about Neomycin[edit source]
neomycin is a broad spectrum aminoglycoside antibiotic whose current use is limited to oral and topical administration.
Liver safety of Neomycin[edit source]
Neomycin has minimal oral absorption and its use has not been linked to instances of acute liver injury.
Mechanism of action of Neomycin[edit source]
Neomycin (nee" oh mye' sin) is an aminoglycoside with a broad spectrum of activity against both gram positive and gram negative organisms. Like other aminoglycosides, neomycin is thought to act by binding to bacterial ribosomes and inhibiting protein synthesis. neomycin has activity against many aerobic gram negative and gram positive bacteria, including the major E.Coli species resident in the colon as well as the enteropathogenic forms of E.Coli known to cause traveler’s diarrhea. Like other aminoglycosides, neomycin is poorly absorbed orally. The lack of absorption from the gastrointestinal tract is the basis of the main use of neomycin, as an oral agent to suppress intestinal bacterial flora.
Oral neomycin is indicated for treatment of infectious diarrhea, for suppression of intestinal bacterial flora in patients undergoing colorectal surgery, and as a means of decreasing colonic bacteria and production of ammonia in hepatic encephalopathy. Topical neomycin is used for burns, wounds and ulcerations and as otic suspensions for external otitis.
Dosage and administration for Neomycin[edit source]
Neomycin is available in multiple generic forms including oral tablets of 500 mg. The typical adult dose of neomycin is 1 to 3 grams daily in four divided doses.
Side effects of Neomycin[edit source]
Long term therapy should be avoided because of the possibility of some systemic absorption and the high rate of oto- and nephrotoxicity associated with neomycin use. Other adverse events include nausea, diarrhea, and Clostridium difficile related colitis.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
