Familiar chronic mucocutaneous candidiasis
(Redirected from Familiar chronic mucocutaneous candidiasis - Not a rare disease)
Other Names: CMC; Chronic mucocutaneous candidiasis; Familial candidiasis
Chronic mucocutaneous candidosis (CMC) refers to a group of heterogenous disorders characterized by persistent, debilitating and/or recurrent infections of the skin, nails, and mucus membranes, mainly with the fungal pathogen Candida albicans.
Cause[edit | edit source]
Chronic mucocutaneous candidiasis can be inherited either autosomal dominant or autosomal recessive. There are 9 types of this condition with the first CANDF1 being located at 2p22.3-p21 (cytogenetically).
Symptoms and signs[edit | edit source]
The symptoms of this condition are hyperkeratosis, skin ulcer, dyspareunia, endocardium abnormality, vision problems, hepatitis, seizures, hematuria and meningitis.
Diagnosis[edit | edit source]
Chronic mucocutaneous candidiasis can be diagnosed in an affected individual via the following methods/tests:
- Thyroid function test
- Liver function test
- Cellular immunity test
- Skin biopsy
- Genetic testing
Treatment[edit | edit source]
Management for an individual with chronic mucocutaneous candidiasis consists of the following (relapse occurs once treatment is ceased, in many cases):
- Systemic antifungal therapy(e.g. Fluconazole)
- Transfer factor
- Combination therapy
- Screening (annually)
NIH genetic and rare disease info[edit source]
Familiar chronic mucocutaneous candidiasis is a rare disease.
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