GABRP
GABRP or Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene. It is a member of the GABA receptor family, which are integral membrane proteins that respond to the neurotransmitter gamma-aminobutyric acid (GABA).
Function[edit | edit source]
GABRP is a subunit of the GABA-A receptor, which is a pentameric ligand-gated ion channel. This receptor is the primary inhibitory neurotransmitter receptor in the brain. The GABRP subunit is expressed in several non-neuronal tissues including the uterus, where it may be involved in uterine contractility.
Structure[edit | edit source]
The GABRP protein is composed of four transmembrane domains with both the N- and C-terminus located extracellularly. The protein forms a pentameric channel that is permeable to chloride ions when activated by GABA.
Clinical significance[edit | edit source]
Alterations in GABRP expression have been associated with several disorders including epilepsy, schizophrenia, and alcohol dependence. In particular, increased expression of GABRP has been observed in the brains of individuals with alcohol dependence, suggesting a potential role in the development of this disorder.
Research[edit | edit source]
Research into GABRP has focused on its role in various neurological and psychiatric disorders. In addition, its expression in non-neuronal tissues suggests it may have roles outside of the nervous system that are yet to be fully understood.
See also[edit | edit source]
References[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
