Propantheline bromide

Propantheline bromide is a pharmacological agent classified under the category of anticholinergic drugs. It is primarily used in the treatment of conditions such as peptic ulcer disease and hyperhidrosis.

Pharmacology

Propantheline bromide is a quaternary ammonium compound that acts as a competitive inhibitor of acetylcholine at postganglionic parasympathetic receptor sites. This results in decreased activity of the parasympathetic nervous system, leading to effects such as reduced gastric acid secretion and decreased sweating.

Clinical Uses

Propantheline bromide is used in the management of peptic ulcer disease due to its ability to reduce gastric acid secretion. It is also used in the treatment of hyperhidrosis, a condition characterized by excessive sweating, as it can decrease sweat production.

Side Effects

Common side effects of propantheline bromide include dry mouth, blurred vision, and urinary retention. These are due to the drug's anticholinergic effects. More serious side effects can include tachycardia, glaucoma, and intestinal obstruction.

Contraindications

Propantheline bromide is contraindicated in patients with glaucoma, myasthenia gravis, and intestinal obstruction. It should also be used with caution in elderly patients due to the increased risk of anticholinergic side effects.

Interactions

Propantheline bromide can interact with other medications, including other anticholinergic drugs, antidepressants, and antihistamines. These interactions can increase the risk of side effects.

See Also

• Anticholinergic
• Peptic ulcer disease
• Hyperhidrosis