Artane

From WikiMD's Wellness Encyclopedia


Artane
[[File:|frameless|220px|alt=|]]
INN
Drug class
Routes of administration Oral
Pregnancy category
Bioavailability
Metabolism Hepatic
Elimination half-life 6-10 hours
Excretion Renal
Legal status
CAS Number 52-49-3
PubChem 5566
DrugBank DB00376
ChemSpider 5366
KEGG D00381


Artane is the brand name for the drug Trihexyphenidyl, which is an anticholinergic medication used primarily to treat Parkinson's disease and extrapyramidal symptoms caused by antipsychotic medications.

Medical Uses[edit | edit source]

Artane is used to manage symptoms of Parkinson's disease, such as tremor, rigidity, and bradykinesia. It is also effective in treating extrapyramidal side effects associated with the use of antipsychotic drugs.

Mechanism of Action[edit | edit source]

Artane works by blocking acetylcholine receptors in the central nervous system, which helps to restore the balance between acetylcholine and dopamine in the brain. This action helps to reduce the symptoms of Parkinson's disease and drug-induced parkinsonism.

Side Effects[edit | edit source]

Common side effects of Artane include dry mouth, blurred vision, constipation, urinary retention, and tachycardia. In some cases, it may cause confusion, hallucinations, or memory impairment, especially in older adults.

Contraindications[edit | edit source]

Artane is contraindicated in patients with narrow-angle glaucoma, obstructive gastrointestinal disease, and urinary retention. Caution is advised in patients with cardiovascular disease and elderly patients.

Interactions[edit | edit source]

Artane may interact with other anticholinergic drugs, antihistamines, and tricyclic antidepressants, potentially increasing the risk of side effects. It may also interact with levodopa, used in the treatment of Parkinson's disease.

Dosage[edit | edit source]

The dosage of Artane is individualized based on the patient's response and tolerance. It is typically started at a low dose and gradually increased. The usual adult dose ranges from 1 mg to 15 mg per day, divided into 3 to 4 doses.

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]

Template:Parkinson's disease treatment

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Contributors: Prab R. Tumpati, MD