Linsitinib
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Linsitinib is an experimental drug candidate for the treatment of various types of cancer. It is an inhibitor of the insulin receptor and of the insulin-like growth factor 1 receptor (IGF-1R).[1] This prevents tumor cell proliferation and induces tumor cell apoptosis.[2]
Linsitinib was granted orphan drug designation for adrenocortical carcinoma in March 2012.[3]
Phase II clinical trials were initiated for multiple myeloma, ovarian cancer, hepatocellular carcinoma, and NSCLC, but subsatisfactory results caused research for these indications to be discontinued.[3] A phase III clinical trial found that linsitinib did not increase survival in patients with adrenocortical carcinoma.[4] As of 2017, no clinical trials were in progress.[3]
References[edit | edit source]
- ↑ , Discovery of OSI-906: A selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor, Future Medicinal Chemistry, 2009, Vol. 1(Issue: 6), pp. 1153–71, DOI: 10.4155/fmc.09.89, PMID: 21425998,
- ↑ Linsitinib Full text, , National Cancer Institute,
- ↑ 3.0 3.1 3.2 Linsitinib - AdisInsight Full text, adisinsight.springer.com,
- ↑ , Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study, The Lancet Oncology, Vol. 16(Issue: 4), pp. 426–435, DOI: 10.1016/S1470-2045(15)70081-1, PMID: 25795408, Full text,
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