Interleukin-15

Interleukin-15 (IL-15) is a cytokine that plays a pivotal role in the immune system. It is produced by a variety of cells, including macrophages and dendritic cells, and has a wide range of effects on the immune response.

Structure and Function

IL-15 is a four-α-helix bundle cytokine that shares many biological properties with IL-2. It is involved in the proliferation and differentiation of T cells, B cells, natural killer cells, and macrophages. IL-15 also plays a role in the activation of neutrophils and the production of cytokines.

Role in Immunity

IL-15 is crucial for the development and survival of natural killer cells and memory T cells. It promotes the activation and proliferation of these cells, enhancing the body's ability to respond to infections and diseases. IL-15 also plays a role in autoimmune diseases, as it can stimulate the production of auto-reactive T cells.

Clinical Significance

Due to its role in the immune response, IL-15 has been implicated in a variety of diseases, including cancer, autoimmune diseases, and infectious diseases. It is currently being investigated as a potential therapeutic target in these conditions.

File:Interleukin-15 structure.png

Structure of Interleukin-15

See Also

• Cytokine
• Interleukin
• Immune system
• Autoimmune disease

References

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