Aspirin
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Aspirin[edit | edit source]
Aspirin, scientifically known as acetylsalicylic acid, stands as one of the most ubiquitously employed analgesic and antipyretic medications across the globe, boasting over a century of clinical application.
Introduction[edit | edit source]
Derived from salicylate, Aspirin has not only served as a remedy for pain and fever but has demonstrated efficacy in lowering risks associated with cardiovascular events like heart attacks, clot-induced strokes, and circulatory complications. Many healthcare professionals vouch for and prescribe aspirin for its cardioprotective qualities, especially for patients diagnosed with cardiovascular diseases or those with a history of cardiac or cerebrovascular events.
Benefits and Risks[edit | edit source]
Benefits[edit | edit source]
- Cardiovascular Protection: Daily consumption can aid in decreasing the chances of heart attacks, clot-associated strokes, and circulatory disturbances.
- Neurological Advantages: Those with compromised cerebral circulation might benefit from aspirin therapy.
Risks[edit | edit source]
Despite its therapeutic advantages, aspirin isn't devoid of potential risks. Complications may include:
- Stomach bleeding
- Cerebral hemorrhage
- Kidney dysfunction
- Stroke susceptibility
It's paramount that patients discuss with health professionals to strike a balance between benefits and potential adverse reactions.
Liver Safety[edit | edit source]
High doses of aspirin might pave the way for liver injuries. This includes marked elevations in serum aminotransferase, occasionally accompanied by jaundice. Particularly vulnerable are children with febrile illnesses; they might develop Reye syndrome upon exposure to even lower doses.
Mechanism of Action[edit | edit source]
Classified under nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin acts by inhibiting cyclooxygenases (Cox-1 and Cox-2), enzymes responsible for proinflammatory prostaglandin synthesis, which are mediators for pain and inflammation. Unique to aspirin is its irreversible and noncompetitive inhibition of Cox-1, making its effects relatively persistent. This potent and prolonged action also accounts for aspirin's association with gastric irritations and bleeding.
Clinical Uses[edit | edit source]
Aspirin's therapeutic application spans:
- Mild to moderate pain relief stemming from diverse causes including headaches, traumas, menstrual cramps, and various arthritic conditions.
- Management of juvenile rheumatoid arthritis, systemic lupus erythematosus, rheumatoid arthritis, acute rheumatic fever, and Kawasaki disease.
- Fever management, albeit not recommended for young individuals due to the Reye syndrome risk.
- Prophylactic use in atherosclerosis and post-coronary interventions, typically at a dose of 81 mg daily.
FDA Approval[edit | edit source]
The US welcomed aspirin's clinical introduction in the early 20th century. Presently, it graces many medicine cabinets as an over-the-counter staple, available in its pure form or combined with various other drugs.
Dosage and Administration[edit | edit source]
Typical aspirin dosage ranges between 330 to 660 mg, administered every 4 to 6 hours. For its antiplatelet benefits, particularly in preventing atherosclerotic complications, 81 mg once daily is the norm.
Brand Names[edit | edit source]
Aspirin is marketed under various commercial names, including:
- * Bayer’s aspirin
- * Alka seltzer
- * Anacin
- * Ascriptin
- * Aspergum
- * BC powder
- * Bufferin
- * Ecotrin
- * Excedrin
- * Stanback
See Also[edit | edit source]
Aspirin Resources | ||
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