Aspirin

From WikiMD's Wellness Encyclopedia

(Redirected from Wonder drug)

Aspirin[edit | edit source]

Aspirin, scientifically known as acetylsalicylic acid, stands as one of the most ubiquitously employed analgesic and antipyretic medications across the globe, boasting over a century of clinical application.

Introduction[edit | edit source]

Derived from salicylate, Aspirin has not only served as a remedy for pain and fever but has demonstrated efficacy in lowering risks associated with cardiovascular events like heart attacks, clot-induced strokes, and circulatory complications. Many healthcare professionals vouch for and prescribe aspirin for its cardioprotective qualities, especially for patients diagnosed with cardiovascular diseases or those with a history of cardiac or cerebrovascular events.

Benefits and Risks[edit | edit source]

Benefits[edit | edit source]

  • Cardiovascular Protection: Daily consumption can aid in decreasing the chances of heart attacks, clot-associated strokes, and circulatory disturbances.
  • Neurological Advantages: Those with compromised cerebral circulation might benefit from aspirin therapy.

Risks[edit | edit source]

Despite its therapeutic advantages, aspirin isn't devoid of potential risks. Complications may include:

  • Stomach bleeding
  • Cerebral hemorrhage
  • Kidney dysfunction
  • Stroke susceptibility

It's paramount that patients discuss with health professionals to strike a balance between benefits and potential adverse reactions.

Liver Safety[edit | edit source]

High doses of aspirin might pave the way for liver injuries. This includes marked elevations in serum aminotransferase, occasionally accompanied by jaundice. Particularly vulnerable are children with febrile illnesses; they might develop Reye syndrome upon exposure to even lower doses.

Mechanism of Action[edit | edit source]

Classified under nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin acts by inhibiting cyclooxygenases (Cox-1 and Cox-2), enzymes responsible for proinflammatory prostaglandin synthesis, which are mediators for pain and inflammation. Unique to aspirin is its irreversible and noncompetitive inhibition of Cox-1, making its effects relatively persistent. This potent and prolonged action also accounts for aspirin's association with gastric irritations and bleeding.

Clinical Uses[edit | edit source]

Aspirin's therapeutic application spans:

  • Mild to moderate pain relief stemming from diverse causes including headaches, traumas, menstrual cramps, and various arthritic conditions.
  • Management of juvenile rheumatoid arthritis, systemic lupus erythematosus, rheumatoid arthritis, acute rheumatic fever, and Kawasaki disease.
  • Fever management, albeit not recommended for young individuals due to the Reye syndrome risk.
  • Prophylactic use in atherosclerosis and post-coronary interventions, typically at a dose of 81 mg daily.

FDA Approval[edit | edit source]

The US welcomed aspirin's clinical introduction in the early 20th century. Presently, it graces many medicine cabinets as an over-the-counter staple, available in its pure form or combined with various other drugs.

Dosage and Administration[edit | edit source]

Typical aspirin dosage ranges between 330 to 660 mg, administered every 4 to 6 hours. For its antiplatelet benefits, particularly in preventing atherosclerotic complications, 81 mg once daily is the norm.

Brand Names[edit | edit source]

Aspirin is marketed under various commercial names, including:

See Also[edit | edit source]

Aspirin Resources
Wikipedia

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD