Aspirin

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(Redirected from ZORprin)

Aspirin[edit | edit source]

Aspirin, scientifically known as acetylsalicylic acid, stands as one of the most ubiquitously employed analgesic and antipyretic medications across the globe, boasting over a century of clinical application.

Introduction[edit | edit source]

Derived from salicylate, Aspirin has not only served as a remedy for pain and fever but has demonstrated efficacy in lowering risks associated with cardiovascular events like heart attacks, clot-induced strokes, and circulatory complications. Many healthcare professionals vouch for and prescribe aspirin for its cardioprotective qualities, especially for patients diagnosed with cardiovascular diseases or those with a history of cardiac or cerebrovascular events.

Benefits and Risks[edit | edit source]

Benefits[edit | edit source]

  • Cardiovascular Protection: Daily consumption can aid in decreasing the chances of heart attacks, clot-associated strokes, and circulatory disturbances.
  • Neurological Advantages: Those with compromised cerebral circulation might benefit from aspirin therapy.

Risks[edit | edit source]

Despite its therapeutic advantages, aspirin isn't devoid of potential risks. Complications may include:

  • Stomach bleeding
  • Cerebral hemorrhage
  • Kidney dysfunction
  • Stroke susceptibility

It's paramount that patients discuss with health professionals to strike a balance between benefits and potential adverse reactions.

Liver Safety[edit | edit source]

High doses of aspirin might pave the way for liver injuries. This includes marked elevations in serum aminotransferase, occasionally accompanied by jaundice. Particularly vulnerable are children with febrile illnesses; they might develop Reye syndrome upon exposure to even lower doses.

Mechanism of Action[edit | edit source]

Classified under nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin acts by inhibiting cyclooxygenases (Cox-1 and Cox-2), enzymes responsible for proinflammatory prostaglandin synthesis, which are mediators for pain and inflammation. Unique to aspirin is its irreversible and noncompetitive inhibition of Cox-1, making its effects relatively persistent. This potent and prolonged action also accounts for aspirin's association with gastric irritations and bleeding.

Clinical Uses[edit | edit source]

Aspirin's therapeutic application spans:

  • Mild to moderate pain relief stemming from diverse causes including headaches, traumas, menstrual cramps, and various arthritic conditions.
  • Management of juvenile rheumatoid arthritis, systemic lupus erythematosus, rheumatoid arthritis, acute rheumatic fever, and Kawasaki disease.
  • Fever management, albeit not recommended for young individuals due to the Reye syndrome risk.
  • Prophylactic use in atherosclerosis and post-coronary interventions, typically at a dose of 81 mg daily.

FDA Approval[edit | edit source]

The US welcomed aspirin's clinical introduction in the early 20th century. Presently, it graces many medicine cabinets as an over-the-counter staple, available in its pure form or combined with various other drugs.

Dosage and Administration[edit | edit source]

Typical aspirin dosage ranges between 330 to 660 mg, administered every 4 to 6 hours. For its antiplatelet benefits, particularly in preventing atherosclerotic complications, 81 mg once daily is the norm.

Brand Names[edit | edit source]

Aspirin is marketed under various commercial names, including:

See Also[edit | edit source]

Aspirin Resources
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Contributors: Prab R. Tumpati, MD