Information about Paroxetine [ edit source ] Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used in the therapy of depression , anxiety disorders and obsessive-compulsive disorder.
Liver safety of Paroxetine [ edit source ] Paroxetine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
Mechanism of action of Paroxetine [ edit source ] Paroxetine (pa rox' e teen) is a selective serotonin reuptake inhibitor (SSRI) that acts by blocking the reuptake of serotonin in CNS synaptic clefts, thus increasing serotonin levels in the brain which is associated with its psychiatric effects.
FDA approval information for Paroxetine [ edit source ] Paroxetine was approved for use in the United States in 1992 and it remains in wide use, with more than 15 million prescriptions being filled yearly.
Indications for paroxetine include major depression , obsessive-compulsive disorder, panic disorder, and anxiety disorders including social anxiety, post-trauma stress and generalized anxiety disorder. Paroxetine is also used for headache , premenstrual dysphoric disorder, diabetic neuropathy and premature ejaculation.
Dosage and administration for Paroxetine [ edit source ] Paroxetine is available as tablets of 10, 20, 30 and 40 mg and as an oral suspension in generic forms and under the brand names of Paxil and Pexeva. The recommended dosage for depression in adults is 20 mg once daily, increasing the dosage by 10 mg increments weekly to a maximum of 50 mg. Controlled release tablets are also available that have slightly different dosing recommendations.
Side effects of Paroxetine [ edit source ] Common side effects are drowsiness ,dyspepsia , nausea , headache , increased sweating , increased appetite , weight gain and sexual dysfunction .
The following are antidepressant subclasses and drugs
MAO Inhibitors
Isocarboxazid , Phenelzine , Tranylcypromine
SNRIs
Duloxetine , Levomilnacipran , Venlafaxine
SSRIs
Citalopram , Escitalopram , Fluoxetine , Fluvoxamine , Paroxetine , Sertraline , Vilazodone , Vortioxetine
Tricyclics
Amitriptyline , Amoxapine , Clomipramine , Desipramine , Doxepin , Imipramine , Nortriptyline , Protriptyline , Trimipramine
Miscellaneous
Bupropion , Flibanserin , Mirtazapine , Nefazodone , Trazodone
The following are antidepressant subclasses and drugs
MAO Inhibitors
Isocarboxazid , Phenelzine , Tranylcypromine
SNRIs
Duloxetine , Levomilnacipran , Venlafaxine
SSRIs
Citalopram , Escitalopram , Fluoxetine , Fluvoxamine , Paroxetine , Sertraline , Vilazodone , Vortioxetine
Tricyclics
Amitriptyline , Amoxapine , Clomipramine , Desipramine , Doxepin , Imipramine , Nortriptyline , Protriptyline , Trimipramine
Miscellaneous
Bupropion , Flibanserin , Mirtazapine , Nefazodone , Trazodone
DAT
(DRIs
)
NET
(NRIs
)
Others: Antihistamines (e.g., brompheniramine , chlorphenamine , pheniramine , tripelennamine )Antipsychotics (e.g., loxapine , ziprasidone )Arylcyclohexylamines (e.g., ketamine , phencyclidine )Dopexamine Ephenidine Ginkgo biloba Indeloxazine Nefazodone Opioids (e.g., desmetramadol , methadone , pethidine (meperidine) , tapentadol , tramadol , levorphanol )
SERT
(SRIs
)
Others: A-80426 Amoxapine Antihistamines (e.g., brompheniramine , chlorphenamine , dimenhydrinate , diphenhydramine , mepyramine (pyrilamine) , pheniramine , tripelennamine )Antipsychotics (e.g., loxapine , ziprasidone )Arylcyclohexylamines (e.g., 3-MeO-PCP , esketamine , ketamine , methoxetamine , phencyclidine )Cyclobenzaprine Delucemine Dextromethorphan Dextrorphan Efavirenz Medifoxamine Mesembrine Mifepristone MIN-117 (WF-516) N-Me-5-HT Opioids (e.g., dextropropoxyphene , methadone , pethidine (meperidine) , levorphanol , tapentadol , tramadol )Roxindole
VMATs
Others
mAChRs
Agonists Antagonists
3-Quinuclidinyl benzilate 4-DAMP Aclidinium bromide (+formoterol )Abediterol AF-DX 250 AF-DX 384 Ambutonium bromide Anisodamine Anisodine Antihistamines (first-generation) (e.g., brompheniramine , buclizine , captodiame , chlorphenamine (chlorpheniramine) , cinnarizine , clemastine , cyproheptadine , dimenhydrinate , dimetindene , diphenhydramine , doxylamine , meclizine , mepyramine (pyrilamine) , mequitazine , perlapine , phenindamine , pheniramine , phenyltoloxamine , promethazine , propiomazine , triprolidine )AQ-RA 741 Atropine Atropine methonitrate Atypical antipsychotics (e.g., clozapine , fluperlapine , olanzapine (+fluoxetine ), rilapine , quetiapine , tenilapine , zotepine )Benactyzine Benzatropine (benztropine) Benzilone Benzilylcholine mustard Benzydamine BIBN 99 Biperiden Bornaprine Camylofin CAR-226,086 CAR-301,060 CAR-302,196 CAR-302,282 CAR-302,368 CAR-302,537 CAR-302,668 Caramiphen Cimetropium bromide Clidinium bromide Cloperastine CS-27349 Cyclobenzaprine Cyclopentolate Darifenacin DAU-5884 Desfesoterodine Dexetimide DIBD Dicycloverine (dicyclomine) Dihexyverine Difemerine Diphemanil metilsulfate Ditran Drofenine EA-3167 EA-3443 EA-3580 EA-3834 Emepronium bromide Etanautine Etybenzatropine (ethybenztropine) Fenpiverinium Fentonium bromide Fesoterodine Flavoxate Glycopyrronium bromide (+beclometasone/formoterol , +indacaterol )Hexahydrodifenidol Hexahydrosiladifenidol Hexbutinol Hexocyclium Himbacine HL-031,120 Homatropine Imidafenacin Ipratropium bromide (+salbutamol )Isopropamide J-104,129 Hyoscyamine Mamba toxin 3 Mamba toxin 7 Mazaticol Mebeverine Meladrazine Mepenzolate Methantheline Methoctramine Methylatropine Methylhomatropine Methylscopolamine Metixene Muscarinic toxin 7 N-Ethyl-3-piperidyl benzilate N-Methyl-3-piperidyl benzilate Nefopam Octatropine methylbromide (anisotropine methylbromide) Orphenadrine Otenzepad (AF-DX 116) Otilonium bromide Oxapium iodide Oxitropium bromide Oxybutynin Oxyphencyclimine Oxyphenonium bromide PBID PD-102,807 PD-0298029 Penthienate Pethidine pFHHSiD Phenglutarimide Phenyltoloxamine Pipenzolate bromide Piperidolate Pirenzepine Piroheptine Pizotifen Poldine Pridinol Prifinium bromide Procyclidine Profenamine (ethopropazine) Propantheline bromide Propiverine Quinidine Revefenacin Rociverine RU-47,213 SCH-57,790 SCH-72,788 SCH-217,443 Scopolamine (hyoscine) Scopolamine butylbromide (hyoscine butylbromide) Silahexacyclium Sofpironium bromide Solifenacin SSRIs
(e.g., femoxetine , paroxetine )
Telenzepine Terodiline Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin , mirtazapine )Tiemonium iodide Timepidium bromide Tiotropium bromide Tiquizium bromide Tofenacin Tolterodine Tricyclic antidepressants (e.g., amitriptyline (+perphenazine ), amitriptylinoxide , butriptyline , cidoxepin , clomipramine , desipramine , desmethyldesipramine , dibenzepin , dosulepin (dothiepin) , doxepin , imipramine , lofepramine , nitroxazepine , northiaden (desmethyldosulepin) , nortriptyline , protriptyline , quinupramine , trimipramine )Tridihexethyl Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine , chlorprothixene , cyamemazine (cyamepromazine) , loxapine , mesoridazine , thioridazine )Umeclidinium bromide (+vilanterol )WIN-2299 Xanomeline Zamifenacin
Precursors (and prodrugs )
Subsidiaries Predecessors, Products
Current
Pharmaceuticals Vaccines Other
Former
People
Litigation Other
Translate this page: - East Asian
中文 ,
日本 ,
한국어 ,
South Asian
हिन्दी ,
தமிழ் ,
తెలుగు ,
Urdu ,
ಕನ್ನಡ ,
Southeast Asian
Indonesian ,
Vietnamese ,
Thai ,
မြန်မာဘာသာ ,
বাংলা
European
español ,
Deutsch ,
français ,
Greek ,
português do Brasil ,
polski ,
română ,
русский ,
Nederlands ,
norsk ,
svenska ,
suomi ,
Italian
Middle Eastern & African
عربى ,
Turkish ,
Persian ,
Hebrew ,
Afrikaans ,
isiZulu ,
Kiswahili ,
Other
Bulgarian ,
Hungarian ,
Czech ,
Swedish ,
മലയാളം ,
मराठी ,
ਪੰਜਾਬੀ ,
ગુજરાતી ,
Portuguese ,
Ukrainian
WikiMD is not a substitute for professional medical advice . See full disclaimer .Credits:Most images are courtesy of Wikimedia commons , and templates Wikipedia , licensed under CC BY SA or similar.
