Alphacetylmethadol
Alphacetylmethadol (also known as ACEM or LAAM) is a synthetic opioid used in the treatment of opioid addiction. It is a long-acting derivative of methadone and is chemically similar to levo-alpha-acetylmethadol (LAAM).
History[edit | edit source]
Alphacetylmethadol was first synthesized in the 1940s as part of a research program aimed at developing opioid analgesics with improved pharmacological properties. It was later developed as a treatment for opioid addiction in the 1970s.
Pharmacology[edit | edit source]
Alphacetylmethadol is a mu-opioid receptor agonist. It works by mimicking the effects of opioids in the brain, thereby reducing cravings and withdrawal symptoms in opioid-dependent individuals. Alphacetylmethadol is metabolized in the liver and has a long half-life, which allows for less frequent dosing compared to other opioid replacement therapies.
Clinical Use[edit | edit source]
Alphacetylmethadol is used in the treatment of opioid addiction. It is typically administered in a clinic setting under the supervision of a healthcare provider. The dosage is individualized based on the patient's opioid tolerance and response to treatment.
Side Effects[edit | edit source]
Common side effects of alphacetylmethadol include constipation, drowsiness, and nausea. Serious side effects may include respiratory depression, QT prolongation, and dependence.
Legal Status[edit | edit source]
In the United States, alphacetylmethadol is classified as a Schedule II controlled substance, indicating a high potential for abuse and dependence.
See Also[edit | edit source]
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