Heterocodeine

Heterocodeine

Heterocodeine is a semi-synthetic opioid narcotic introduced to the international pharmaceuticals market in the 1950s. It is a derivative of codeine, designed to be more potent and have a better bioavailability.

Chemistry

Heterocodeine, also known as 6-methyldihydrocodeine, is a methylated derivative of dihydrocodeine. Its chemical structure is similar to that of codeine, but it has an additional methyl group at the 6 position. This modification increases the potency of heterocodeine compared to its parent compound.

Pharmacology

Heterocodeine acts as an agonist at the mu-opioid receptor, the main site of action for the most commonly used opioids. Its potency is approximately 1.5 times that of codeine. Like other opioids, it produces analgesia, sedation, euphoria, and respiratory depression.

Medical Use

Heterocodeine is used for the relief of moderate to severe pain. It can also be used as a cough suppressant, although this use is less common due to the availability of less potent and potentially less addictive alternatives.

Side Effects

Common side effects of heterocodeine include drowsiness, dizziness, nausea, vomiting, constipation, and respiratory depression. Like other opioids, it has a high potential for addiction and dependence.

Legal Status

In many countries, heterocodeine is a controlled substance due to its potential for abuse and addiction. It is typically classified in the same category as other potent opioids, such as morphine and heroin.

See Also

• Opioid
• Codeine
• Dihydrocodeine
• Morphine