Semorphone

Semorphone

Semorphone is a semi-synthetic opioid that is derived from morphine. It is a potent analgesic that is used in the management of severe pain. Semorphone is also known as 14-Hydroxydihydromorphinone and is marketed under various brand names including Palladone and Dilaudid.

Chemistry

Semorphone is a hydrogenated ketone of morphine. It is made by the hydrogenation of morphine in the presence of a catalyst. The chemical structure of semorphone is similar to that of morphine, but it has a hydroxyl group at the 14th carbon atom instead of a methoxy group. This modification increases the potency of semorphone compared to morphine.

Pharmacology

Semorphone is a mu-opioid receptor agonist. It works by binding to the mu-opioid receptors in the brain and spinal cord, which are involved in the perception of pain. By binding to these receptors, semorphone inhibits the release of substance P, a neurotransmitter involved in the transmission of pain signals. This results in a decrease in the perception of pain.

Clinical Use

Semorphone is used in the management of severe pain that is not responsive to non-opioid analgesics. It is also used in the management of pain in patients with terminal illnesses such as cancer. Semorphone is available in various forms including tablets, injections, and suppositories.

Side Effects

Like other opioids, semorphone has several side effects. These include nausea, vomiting, constipation, dizziness, and respiratory depression. Long-term use of semorphone can lead to physical dependence and addiction.

See Also

• Opioid
• Morphine
• Analgesic
• Mu-opioid receptor
• Substance P