Etonitazene
Etonitazene is an opioid analgesic drug that was first synthesized in 1957 by a team at Hoffmann-La Roche. It is related to the more well-known opioid etorphine, which is used as a very potent veterinary painkiller for large animals such as elephants. However, etonitazene is over 1000-1500 times more potent than morphine in animal models, making it one of the most potent opioids known.
Chemistry[edit | edit source]
Etonitazene is part of the benzimidazole class of opioids. It is chemically described as 2-(4-ethoxybenzyl)-1-(1-ethylpropyl)-1H-benzo[d]imidazole. The drug has a complex structure that involves several different functional groups, including an ether group, a propyl group, and a benzimidazole ring.
Pharmacology[edit | edit source]
Like other opioids, etonitazene works by binding to the mu-opioid receptor in the brain and spinal cord. This binding action inhibits the transmission of pain signals and produces a range of effects including analgesia, sedation, and euphoria. The drug's extremely high potency is thought to be due to its high lipophilicity, which allows it to cross the blood-brain barrier more easily than less lipophilic opioids.
Legal Status[edit | edit source]
Due to its high potency and potential for abuse, etonitazene is classified as a Schedule I controlled substance in the United States and is similarly controlled in many other countries. It is illegal to manufacture, distribute, or possess the drug without a license.
Health Risks[edit | edit source]
The use of etonitazene carries significant health risks, including a high risk of overdose due to its extreme potency. Symptoms of overdose can include respiratory depression, unconsciousness, and death. Long-term use can lead to physical dependence and withdrawal symptoms upon cessation of use.
See Also[edit | edit source]
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