Depodur
Extended-release liposomal bupivacaine
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Depodur is a brand name for an extended-release liposomal formulation of bupivacaine, a local anesthetic used for pain management. It is specifically designed for epidural administration to provide prolonged pain relief, typically used in the context of postoperative pain management.
Mechanism of Action[edit | edit source]
Depodur works by blocking sodium channels in neurons, which inhibits the initiation and conduction of nerve impulses. This action results in a loss of sensation in the targeted area, providing effective pain relief.
Clinical Use[edit | edit source]
Depodur is primarily used for postoperative pain management. It is administered via the epidural route, which allows for direct delivery to the spinal cord and surrounding nerves. The extended-release formulation provides prolonged pain relief, reducing the need for additional doses of analgesics.
Advantages[edit | edit source]
The extended-release nature of Depodur offers several advantages:
- Prolonged pain relief
- Reduced need for additional analgesics
- Potentially fewer side effects compared to systemic opioids
Side Effects[edit | edit source]
Common side effects of Depodur may include:
Contraindications[edit | edit source]
Depodur should not be used in patients with:
- Known hypersensitivity to bupivacaine or other amide-type local anesthetics
- Severe hypotension
- Infection at the site of injection
Related Pages[edit | edit source]
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Contributors: Prab R. Tumpati, MD
