Depodur

Depodur is a brand name for an extended-release liposomal formulation of bupivacaine, a local anesthetic used for pain management. It is specifically designed for epidural administration to provide prolonged pain relief, typically used in the context of postoperative pain management.

Mechanism of Action

Depodur works by blocking sodium channels in neurons, which inhibits the initiation and conduction of nerve impulses. This action results in a loss of sensation in the targeted area, providing effective pain relief.

Clinical Use

Depodur is primarily used for postoperative pain management. It is administered via the epidural route, which allows for direct delivery to the spinal cord and surrounding nerves. The extended-release formulation provides prolonged pain relief, reducing the need for additional doses of analgesics.

Advantages

The extended-release nature of Depodur offers several advantages:

• Prolonged pain relief
• Reduced need for additional analgesics
• Potentially fewer side effects compared to systemic opioids

Side Effects

Common side effects of Depodur may include:

• Hypotension
• Nausea
• Vomiting
• Pruritus
• Urinary retention

Contraindications

Depodur should not be used in patients with:

• Known hypersensitivity to bupivacaine or other amide-type local anesthetics
• Severe hypotension
• Infection at the site of injection

Related Pages

• Bupivacaine
• Local anesthetic
• Epidural administration
• Postoperative pain management