C-C motif chemokine ligand 27

C-C motif chemokine ligand 27 (CCL27), also known as cutaneous T-cell-attracting chemokine (CTACK), is a protein that in humans is encoded by the CCL27 gene. It is a member of the chemokine family, a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors.

Function

CCL27 is a chemokine that attracts skin-associated memory T cells. It is expressed in the skin and thymus. The chemokine is found at high levels in the skin and it has been shown to attract T cells via the CCR10 receptor. This chemokine is also thought to have a role in T cell homing to skin sites.

Clinical significance

CCL27 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. It has been supposed to have a role in allergic reactions and may also play a role in the development of autoimmune diseases.

See also

• Chemokine
• Chemokine receptor
• C-C chemokine receptors

External links

• GeneCards: CCL27