Alpha-Ethylphenethylamine

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Alpha-Ethylphenethylamine (also known as Etphenidine) is a psychoactive drug and research chemical of the phenethylamine and diarylethylamine classes that has been sold online as a designer drug. It acts as an agonist for the 5-HT2A receptor.

Chemistry[edit | edit source]

Alpha-Ethylphenethylamine is a phenethylamine with the formula C10H15N. It is a structural isomer of amphetamine, differing only in the position of the ethyl group. This change in structure imparts significant differences in pharmacology.

Pharmacology[edit | edit source]

Alpha-Ethylphenethylamine acts primarily as a 5-HT2A receptor agonist. The 5-HT2A receptor is responsible for the cognitive, perceptual, and other mental effects that are the hallmark of the hallucinogenic experience. It also has some activity at the dopamine receptor and norepinephrine receptor, which may contribute to its psychoactive effects.

Effects[edit | edit source]

The effects of Alpha-Ethylphenethylamine are similar to those of other psychedelic drugs. Users report altered thinking processes, closed and open eye visuals, synesthesia, an altered sense of time, and spiritual experiences. It also has stimulant effects, increasing energy, focus, and sociability.

Legal Status[edit | edit source]

The legal status of Alpha-Ethylphenethylamine varies by country, but it is often considered a controlled substance due to its potential for abuse and addiction.

See Also[edit | edit source]

References[edit | edit source]

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Contributors: Prab R. Tumpati, MD