Phenobarbitone

Phenobarbitone (also known as Phenobarbital or Luminal) is a medication that is primarily used to treat seizure disorders such as epilepsy, and in the short-term management of anxiety and insomnia. It is classified as a barbiturate, a type of drug that works by depressing the central nervous system.

Pharmacology

Phenobarbitone works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that inhibits the activity of the nervous system. This results in a calming effect, which can help to prevent seizures and reduce anxiety.

Uses

Phenobarbitone is used in the treatment of all types of seizures except absence seizures. It is also used to relieve anxiety and induce sleep in the short-term. In addition, it is used in the treatment of drug withdrawal syndromes, particularly those caused by alcohol withdrawal and benzodiazepine withdrawal.

Side Effects

Common side effects of Phenobarbitone include drowsiness, dizziness, and loss of coordination. More serious side effects can include respiratory depression, addiction, and suicidal thoughts.

History

Phenobarbitone was first synthesized in 1912 and was widely used throughout the 20th century for its sedative and hypnotic properties. It was later replaced by safer and more effective medications, but it is still used in some cases for its anticonvulsant properties.

See Also

• Barbiturate
• Epilepsy
• Anxiety
• Insomnia

Phenobarbitone Resources
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