Teprotumumab-trbw

What is Teprotumumab-trbw?

• Teprotumumab-trbw (TEPEZZA) is an insulin-like growth factor-1 receptor inhibitor.

What are the uses of this medicine?

• This medicine is used for the treatment of Thyroid Eye Disease.

How does this medicine work?

• Teprotumumab-trbw's mechanism of action in patients with Thyroid Eye Disease has not been fully characterized.
• Teprotumumab-trbw binds to IGF-1R and blocks its activation and signaling.

Who Should Not Use this medicine ?

• This medicine have no usage limitations.

Is this medicine FDA approved?

• It was approved for use in the United States in 2020.

How should this medicine be used?

Recommended Dosage

• The recommended dose of TEPEZZA is an intravenous infusion of 10 mg/kg for the initial dose followed by an intravenous infusion of 20 mg/kg every three weeks for 7 additional infusions.

Administration

• Administer the diluted solution intravenously over 90 minutes for the first two infusions.
• If well tolerated, the minimum time for subsequent infusions can be reduced to 60 minutes.
• If not well tolerated, the minimum time for subsequent infusions should remain at 90 minutes.
• Do not administer as an intravenous push or bolus.
• TEPEZZA should not be infused concomitantly with other agents.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Injection: 500 mg lyophilized powder in a single-dose vial for reconstitution

This medicine is available in fallowing brand namesː

• TEPEZZA

What side effects can this medication cause?

The most common side effects of this medicine include:

• muscle spasm
• nausea
• alopecia
• diarrhea
• fatigue
• hyperglycemia
• hearing impairment
• dry skin
• dysgeusia
• headache

What special precautions should I follow?

• Infusion reactions may occur.If an infusion reaction occurs, interrupt or slow the rate of infusion and use appropriate medical management.
• Monitor patients with preexisting Inflammatory Bowel Disease (IBD) for flare of disease; discontinue TEPEZZA if IBD worsens.
• This medicine may cause hyperglycemia.
• Monitor glucose levels in all patients; treat hyperglycemia with glycemic control medications.

What to do in case of emergency/overdose?

• No information is available for patients who have received an overdosage.

Can this medicine be used in pregnancy?

• There are insufficient data with TEPEZZA use in pregnant women to inform any drug associated risks for adverse developmental outcomes.

Can this medicine be used in children?

• Safety and effectiveness have not been established in pediatric patients.

What should I know about storage and disposal of this medication?

• Refrigerate at 2°C to 8°C (36°F to 46°F) in original carton until time of use to protect from light. Do not freeze.

• Dailymed label info on Teprotumumab-trbw
• FDA Teprotumumab-trbw

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