Proterguride
| Drug Information | |||
|---|---|---|---|
| Image | 200 | ||
| Identifiers
DrugBank
ChEBI
|
Chemical Data
| ||
Proterguride is a dopamine receptor agonist that has been studied for its potential use in treating Parkinson's disease and other conditions related to dopamine deficiency. It is a member of the ergoline class of compounds, which are known for their activity on the central nervous system.
Pharmacology[edit | edit source]
Proterguride acts primarily as an agonist at the dopamine D2 receptors, which are involved in the regulation of movement and coordination. By stimulating these receptors, proterguride can help alleviate symptoms of Parkinson's disease, such as tremors and rigidity. Additionally, it has some activity at the serotonin receptors, which may contribute to its effects on mood and cognition.
Mechanism of Action[edit | edit source]
The mechanism of action of proterguride involves its binding to and activation of dopamine receptors in the brain. This leads to an increase in dopaminergic activity, which is beneficial in conditions where dopamine levels are low, such as in Parkinson's disease. The activation of serotonin receptors may also play a role in modulating mood and anxiety, which are often comorbid with Parkinson's disease.
Clinical Uses[edit | edit source]
While proterguride has shown promise in preclinical studies, its clinical use is not widespread. It has been investigated for its potential to treat Parkinson's disease and restless legs syndrome, but more research is needed to fully understand its efficacy and safety profile.
Side Effects[edit | edit source]
As with other dopamine agonists, proterguride may cause side effects such as nausea, dizziness, and hallucinations. Long-term use can lead to complications such as impulse control disorders, including compulsive gambling and hypersexuality.
Research[edit | edit source]
Research on proterguride is ongoing, with studies focusing on its pharmacokinetics, long-term safety, and potential applications in other neurological disorders. Its unique profile as a dopamine and serotonin receptor agonist makes it a compound of interest for further investigation.
Also see[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
