Th17

Th17 cells are a subset of pro-inflammatory T cells that produce interleukin 17 (IL-17). They are considered developmentally distinct from Th1 and Th2 cells and play a key role in mucosal immunity and autoimmunity.

Development

Th17 cells develop from naive T cell precursors in response to interleukin-6 (IL-6) and transforming growth factor beta (TGF-β). The differentiation of Th17 cells is further promoted by interleukin-23 (IL-23). This process is regulated by the transcription factor RORγt.

Function

Th17 cells play a crucial role in the immune response to extracellular bacteria and fungi. They produce several cytokines, including IL-17A, IL-17F, interleukin-22 (IL-22), and interleukin-26 (IL-26), which help recruit neutrophils and macrophages to the site of infection.

Role in disease

While Th17 cells are important for host defense, their dysregulation can lead to autoimmune diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis. Therapies that target the IL-17 pathway are currently being developed for these conditions.

See also

• T helper cell
• Cytokine
• Autoimmunity

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External links

• Th17 cells at the US National Library of Medicine Medical Subject Headings (MeSH)

File:Th17 cell differentiation and function.jpg

Th17 cell differentiation and function.