Th17
Th17 cells are a subset of pro-inflammatory T cells that produce interleukin 17 (IL-17). They are considered developmentally distinct from Th1 and Th2 cells and play a key role in mucosal immunity and autoimmunity.
Development[edit | edit source]
Th17 cells develop from naive T cell precursors in response to interleukin-6 (IL-6) and transforming growth factor beta (TGF-β). The differentiation of Th17 cells is further promoted by interleukin-23 (IL-23). This process is regulated by the transcription factor RORγt.
Function[edit | edit source]
Th17 cells play a crucial role in the immune response to extracellular bacteria and fungi. They produce several cytokines, including IL-17A, IL-17F, interleukin-22 (IL-22), and interleukin-26 (IL-26), which help recruit neutrophils and macrophages to the site of infection.
Role in disease[edit | edit source]
While Th17 cells are important for host defense, their dysregulation can lead to autoimmune diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis. Therapies that target the IL-17 pathway are currently being developed for these conditions.
See also[edit | edit source]
 | This immunology article is a stub. You can help WikiMD by expanding it. |
 | This medical article is a stub. You can help WikiMD by expanding it. |
References[edit | edit source]
External links[edit | edit source]
- Th17 cells at the US National Library of Medicine Medical Subject Headings (MeSH)
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
