N-Benzylnaltrindole
A chemical compound used in scientific research as a selective antagonist of the delta opioid receptor.
N-Benzylnaltrindole (BNTX) is a chemical compound that acts as a selective antagonist of the delta opioid receptor. It is used primarily in scientific research to study the role of delta opioid receptors in various physiological processes.
Chemical Structure and Properties[edit | edit source]
N-Benzylnaltrindole is a derivative of naltrindole, which itself is a potent and selective delta opioid receptor antagonist. The addition of a benzyl group to the nitrogen atom in the indole ring of naltrindole enhances its selectivity for the delta opioid receptor.
The IUPAC name of N-Benzylnaltrindole is (2S)-2-[(5R,6R,7R,14S)-14-hydroxy-7-benzyl-9-methoxy-1,2,3,4,5,6-hexahydro-8H-5,6-epoxy-3,14-ethano-17-methyl-6,14-ethano-17H-dibenzo[a,g]quinolizin-8-yl]-3,3-dimethylbutanamide. Its molecular formula is C₃₆H₄₀N₂O₅, and it has a molecular weight of 580.72 g/mol.
Pharmacology[edit | edit source]
N-Benzylnaltrindole is known for its high affinity and selectivity for the delta opioid receptor, which is one of the three main types of opioid receptors, the others being mu and kappa receptors. Delta receptors are involved in modulating mood, analgesia, and other central nervous system functions.
Mechanism of Action As an antagonist, N-Benzylnaltrindole binds to the delta opioid receptor and blocks the action of endogenous opioids and other agonists. This blockade allows researchers to study the specific effects mediated by delta receptors by observing changes in physiological and behavioral responses when the receptor is inhibited.
Research Applications[edit | edit source]
N-Benzylnaltrindole is used in various research settings to explore the role of delta opioid receptors in:
- Pain Management: Understanding how delta receptors contribute to pain perception and modulation.
- Mood Disorders: Investigating the potential role of delta receptors in depression and anxiety.
- Addiction: Studying the involvement of delta receptors in the development and maintenance of addictive behaviors.
Safety and Handling[edit | edit source]
As with many research chemicals, N-Benzylnaltrindole should be handled with care. Appropriate safety measures, including the use of personal protective equipment and working in a well-ventilated area, should be observed.
Also see[edit | edit source]
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