Naltrindole-5'-isothiocyanate

A selective delta opioid receptor antagonist

Naltrindole-5'-isothiocyanate is a chemical compound that acts as a selective antagonist for the delta opioid receptor. It is a derivative of naltrindole, which is a potent and selective delta opioid receptor antagonist. Naltrindole-5'-isothiocyanate is used primarily in research settings to study the role of delta opioid receptors in various physiological and pathological processes.

Chemical Structure and Properties

Naltrindole-5'-isothiocyanate is a complex organic molecule with the chemical formula C₃₆H₃₅N₃O₄S. It contains several functional groups, including an isothiocyanate group, which is responsible for its reactivity and ability to form covalent bonds with target proteins. The presence of the isothiocyanate group distinguishes it from its parent compound, naltrindole.

Mechanism of Action

Naltrindole-5'-isothiocyanate functions by binding to the delta opioid receptor, a G protein-coupled receptor that is involved in modulating pain perception, mood, and other neurological functions. By acting as an antagonist, it blocks the receptor's activity, preventing endogenous opioids or other agonists from exerting their effects. This makes it a valuable tool for investigating the physiological roles of delta opioid receptors.

Research Applications

Naltrindole-5'-isothiocyanate is primarily used in neuroscience and pharmacology research. It helps scientists understand the involvement of delta opioid receptors in pain modulation, addiction, and mood disorders. Studies using this compound have contributed to the development of new therapeutic strategies for managing pain and treating opioid addiction.

Safety and Handling

As with many research chemicals, naltrindole-5'-isothiocyanate should be handled with care. It is important to use appropriate personal protective equipment (PPE) and follow safety protocols to avoid exposure. The compound should be stored in a cool, dry place, away from light and moisture.

Also see

• Delta opioid receptor
• Naltrindole
• Opioid receptor
• Opioid antagonist

Receptor Antagonists
Receptor Type	Example Antagonists
Adrenergic receptor	Propranolol, Prazosin
Cholinergic receptor	Atropine, Scopolamine
Dopamine receptor	Haloperidol, Clozapine
Histamine receptor	Ranitidine, Diphenhydramine
Serotonin receptor	Ondansetron, Risperidone
Glutamate receptor	Memantine, Ketamine
GABA receptor	Flumazenil, Bicuculline
Opioid receptor	Naloxone, Naltrexone
Angiotensin receptor	Losartan, Valsartan