5α-Dihydronandrolone

5α-Dihydronandrolone (also known as 5α-DHN) is a metabolite of nandrolone, an anabolic steroid. It is formed in the body by the action of the enzyme 5α-reductase on nandrolone. This process is similar to the conversion of testosterone to dihydrotestosterone (DHT).

Chemistry

5α-Dihydronandrolone is a steroid and a derivative of nandrolone. It has a double bond between the first and second carbon atoms, which is reduced in the formation of 5α-DHN. This reduction is catalyzed by the enzyme 5α-reductase.

Pharmacology

5α-Dihydronandrolone is less androgenic than nandrolone, meaning it has less effect on the development and maintenance of male characteristics. This is because it has a lower affinity for the androgen receptor, the protein that mediates the effects of androgens.

Clinical significance

The conversion of nandrolone to 5α-DHN may be significant in the context of anabolic steroid abuse. Some users of nandrolone report less androgenic side effects compared to other anabolic steroids, which may be due to the formation of 5α-DHN. However, more research is needed to confirm this.

See also

• Nandrolone
• 5α-Reductase
• Androgen receptor

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