OR10A5

OR10A5 is a protein that in humans is encoded by the OR10A5 gene. The protein is a member of the olfactory receptor family, which is involved in the detection of smell.

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Gene

The OR10A5 gene is located on chromosome 1, specifically at 1q44. The gene spans approximately 1 kilobase and consists of one exon. The OR10A5 gene is a part of a cluster of similar genes on chromosome 1. This cluster also includes OR10A4, OR10A6, and OR10A7.

Clinical significance

While the specific clinical significance of OR10A5 is not fully understood, olfactory receptors in general have been implicated in various diseases. For example, mutations in olfactory receptors have been associated with a decreased sense of smell, known as anosmia. Further research is needed to determine the specific role of OR10A5 in human health and disease.

File:OR10A5 gene location on human chromosome 1.png

Location of OR10A5 gene on human chromosome 1.

See also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia