OR51B5

OR51B5 is a gene that encodes a protein in the olfactory receptor family. This family is a group of G protein-coupled receptors which are responsible for detecting molecules in the environment and subsequently initiating a neuronal response. The olfactory receptor proteins interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

Function

The olfactory receptor family is the largest in the genome. The family members of OR51B5 are located in a cluster of similar genes and pseudogenes on chromosome 11. This protein is thought to be part of the chemosensory system in the human airways, and may play a role in sperm chemotaxis.

Clinical significance

Mutations in the OR51B5 gene have been associated with a variety of diseases and conditions. For example, a study found that a mutation in this gene was associated with an increased risk of prostate cancer. Further research is needed to fully understand the role of this gene in disease.

Research

Research into the OR51B5 gene and its associated protein is ongoing. Scientists are particularly interested in understanding how this gene contributes to the sense of smell, and how mutations in this gene may contribute to disease.

See also

• Olfactory receptor
• G protein-coupled receptor
• Sperm chemotaxis
• Prostate cancer