Diphenoxylate hydrochloride

Diphenoxylate Hydrochloride is a medication primarily used in the treatment of diarrhea. It is a synthetic opioid that slows down the movement of the intestines, allowing the body to absorb more fluid and reducing the frequency of bowel movements.

Pharmacology

Diphenoxylate Hydrochloride works by slowing down the movement of the intestines. This decrease in motility allows the intestines to absorb more water and electrolytes from the fecal matter, which results in firmer and less frequent stools. It is often combined with atropine to discourage misuse.

Medical Uses

Diphenoxylate Hydrochloride is used to treat diarrhea. It is not a first-line treatment, but is used when other treatments have failed or are not suitable. It is often used in combination with other medications, such as loperamide or bismuth subsalicylate, to manage symptoms.

Side Effects

Common side effects of Diphenoxylate Hydrochloride include drowsiness, dizziness, and dry mouth. More serious side effects can include severe constipation, stomach pain, and allergic reactions. It can also cause physical dependence if used for a long period of time.

Contraindications

Diphenoxylate Hydrochloride should not be used in patients with a known hypersensitivity to the drug, or in patients with diarrhea caused by certain types of bacterial infections. It should also be used with caution in patients with liver disease, as it is metabolized in the liver.

Interactions

Diphenoxylate Hydrochloride can interact with other medications, including other opioids, certain antidepressants, and certain antihistamines. It can also interact with alcohol, increasing the risk of drowsiness and other side effects.

See Also

• Opioid
• Diarrhea
• Atropine
• Loperamide
• Bismuth subsalicylate