JWH-244

Overview

JWH-244 is a synthetic cannabinoid that belongs to the naphthoylindole family. It is a chemical compound that acts as a potent agonist at the cannabinoid receptors in the brain, specifically the CB1 and CB2 receptors. JWH-244 is part of a larger group of synthetic cannabinoids that were initially developed for research purposes but have since been used recreationally due to their psychoactive effects.

Chemical Structure and Properties

JWH-244 has the chemical formula C23H22N2O and a molecular weight of 342.44 g/mol. The structure of JWH-244 includes a naphthoyl group attached to an indole core, which is a common feature among many synthetic cannabinoids. The full IUPAC name of JWH-244 is 1-pentyl-3-(2-methoxyphenylacetyl)indole.

Synthesis

The synthesis of JWH-244 involves the reaction of 1-pentylindole with 2-methoxyphenylacetyl chloride in the presence of a base. This reaction forms the naphthoylindole structure characteristic of JWH compounds.

Pharmacology

JWH-244 acts as a full agonist at the CB1 and CB2 receptors, with a higher affinity for the CB1 receptor. This interaction leads to the activation of the endocannabinoid system, which is responsible for various physiological processes including mood, appetite, and pain sensation.

Effects

The effects of JWH-244 are similar to those of THC, the primary psychoactive component of cannabis. Users may experience euphoria, altered perception, and relaxation. However, synthetic cannabinoids like JWH-244 can also cause adverse effects such as anxiety, paranoia, and tachycardia.

Legal Status

The legal status of JWH-244 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is important to consult local regulations to determine the legality of JWH-244 in a specific area.

Research and Applications

JWH-244, like other synthetic cannabinoids, was initially developed for research purposes to study the endocannabinoid system and the effects of cannabinoid receptor activation. These compounds have been used in scientific studies to better understand the role of cannabinoids in the body and to develop potential therapeutic agents.

Health Risks and Safety

The use of JWH-244 and other synthetic cannabinoids poses significant health risks. These substances can cause severe side effects, including cardiovascular problems, neurological disturbances, and psychological issues. The lack of regulation and quality control in the production of synthetic cannabinoids further increases the risk of harmful effects.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• Endocannabinoid system