Ajulemic acid

Ajulemic acid (also known as CT3, IP-751, JBT-101, or anabasum) is a synthetic cannabinoid with anti-inflammatory and analgesic properties. It is a derivative of THC (tetrahydrocannabinol), which is the primary psychoactive compound found in cannabis. Unlike THC, ajulemic acid does not have significant psychoactive effects, making it a potential therapeutic agent for a variety of medical conditions.

Chemistry

Ajulemic acid is a synthetic analog of THC, specifically a derivative of the THC metabolite THC-COOH (11-nor-9-carboxy-THC). It is synthesized by condensing a suitable cyclohexenone with piperidine and then treating the resulting compound with sulfuric acid to yield ajulemic acid.

Pharmacology

Ajulemic acid acts as a selective agonist at the CB2 receptor, one of the two main cannabinoid receptors in the body. This receptor is primarily found on immune cells and is involved in regulating inflammation and immune response. By activating the CB2 receptor, ajulemic acid can reduce inflammation and pain without causing the psychoactive effects associated with activation of the CB1 receptor, which is the other main cannabinoid receptor and is primarily found in the brain.

Clinical uses

Ajulemic acid has been investigated for its potential use in a variety of medical conditions, including chronic pain, multiple sclerosis, arthritis, and cystic fibrosis. It has shown promise in preclinical and early clinical trials for these conditions, but further research is needed to fully establish its efficacy and safety.

Safety and side effects

In clinical trials, ajulemic acid has been generally well tolerated, with most side effects being mild and transient. The most common side effects include dry mouth, fatigue, and gastrointestinal symptoms. Unlike THC, ajulemic acid does not cause significant psychoactive effects, even at high doses.

Legal status

The legal status of ajulemic acid varies by country and is often tied to the legal status of cannabis and other cannabinoids. In some countries, it is classified as a controlled substance, while in others it is legal for medical use under certain conditions.

See also

• Cannabinoid
• Cannabinoid receptor
• Medical cannabis