JWH-081
Chemical compound
| JWH-081 | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | I-N (Poland)[1] |
| CAS Number | 210179-46-7 |
| PubChem | 10547208 |
| DrugBank | |
| ChemSpider | 8722599 |
| KEGG | |
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors.[2] With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB2(12.4nM).[3] It was discovered by and named after John W. Huffman.
JWH-081 may be neurotoxic to animals when administered in high doses.[4]
Legal status[edit | edit source]
In the United States, JWH-081 is a Schedule I Controlled Substance.[5]
As of October 2015, JWH-081 is a controlled substance in China.[6]
See also[edit | edit source]
References[edit | edit source]
- ↑ Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii (Dz.U. 2011 nr 105 poz. 614) Full text, , Internetowy System Aktów Prawnych, Accessed on: 12 June 2011.
- ↑ , Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding, Drug and Alcohol Dependence, Vol. 60(Issue: 2), pp. 133–40, DOI: 10.1016/s0376-8716(99)00152-0, PMID: 10940540,
- ↑ , Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists, Bioorganic & Medicinal Chemistry, Vol. 13(Issue: 1), pp. 89–112, DOI: 10.1016/j.bmc.2004.09.050, PMID: 15582455,
- ↑ , Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210, Biomolecules & Therapeutics, Vol. 23(Issue: 6), pp. 597–603, DOI: 10.4062/biomolther.2015.057, PMID: 26535086, PMC: 4624077,
- ↑ Controlled Substances listed by the DEA
- ↑ 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 Full text, , China Food and Drug Administration, 27 September 2015, Accessed on: 1 October 2015.
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