JWH-081
JWH-081 is a synthetic cannabinoid found in several versions of the herbal mixture "Spice." Illicit use of this Spice cannabinoid has been associated with multiple serious side effects. The JWH-081 compound was developed by researcher John W. Huffman at Clemson University.
Chemistry[edit | edit source]
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, almost 10x less affinity for CB2.
Effects[edit | edit source]
The effects of JWH-081 on the human brain are similar to those of cannabis, but it is much more potent than THC. Side effects may include hypertension, tachycardia, myocardial infarction, agitation, vomiting, hallucinations, psychoses, seizures, convulsions and panic attacks.
Legal Status[edit | edit source]
As of October 2015, JWH-081 is a controlled substance in China. JWH-081 is also banned in New Zealand. The compound is illegal in Latvia since 14 November 2013. It is also an Anlage II controlled drug in Germany.
See Also[edit | edit source]
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