Carbinoxamine

What is Carbinoxamine?

• Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront, Ryvent) is a histamine-H 1 receptor blocking agent used for symptoms of allergic rhinitis and the common cold.

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Carbinoxamine

What are the uses of this medicine?

Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront, Ryvent) is effective for the symptomatic treatment of:

• Seasonal and perennial allergic rhinitis.
• Vasomotor rhinitis.
• Allergic conjunctivitis due to inhalant allergens and foods.
• Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
• Dermatographism
• As therapy for anaphylactic reactions adjunctive to epinephrine.
• Amelioration of the severity of allergic reactions to blood or plasma.

How does this medicine work?

• Carbinoxamine maleate, an ethanolamine derivative, is an antihistamine with anticholinergic (drying) and sedative properties.
• Carbinoxamine appears to compete with histamine (type H1) for receptor sites on effector cells in the gastrointestinal tract, blood vessels and respiratory tract.

Who Should Not Use this medicine ?

This medicine cannot be used:

• in children younger than 2 years of age.
• in nursing mothers.
• in patients who are hypersensitive to the drug or on monoamine oxidase inhibitor therapy.

What drug interactions can this medicine cause?

• Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Be sure to mention any of the following:

• Monoamine oxidase inhibitors
• alcohol and other CNS depressants (hypnotics sedatives, tranquilizers, etc.).

Is this medicine FDA approved?

• It was patented in 1947 and came into medical use in 1953.
• It was first launched in the United States by the McNeil Corporation under the brand name Clistin.

How should this medicine be used?

• Carbinoxamine maleate dosage should be based on the severity of the condition and the response of the patient.

Recommended dosage: Tablets: Usual Adult Dosage:

• 1 or 2 tablets (4 to 8 mg) 3 to 4 times daily.

Usual Child’s Dosage:

• Six to eleven years – 1/2 to 1 tablet (2 to 4 mg) 3 to 4 times daily.

Oral Solution: Usual Adult Dosage:

• 1 or 2 teaspoonfuls (4 to 8 mg) 3 to 4 times daily.

Usual Child's Dosage (approximately 0.2 to 0.4 mg/kg/day, divided into 3 to 4 doses):

• Six to eleven years - ½ to 1 teaspoonful (2 to 4 mg) 3 to 4 times daily.
• Dosing for children 2 to 5 years of age should be based on weight whenever possible.
• The usual dosage for children 2 to 5 years of age is approximately 0.2 to 0.4 mg/kg/day, divided into 3 to 4 daily doses.
• In general, this corresponds to a dose of 1/4 to 1/2 teaspoonful (1 to 2 mg) 3 to 4 times daily.

Administration:

• Carbinoxamine maleate should be taken on an empty stomach with water.
• Take this medication by mouth as directed by your doctor.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Carbinoxamine Maleate Tablets
• Carbinoxamine Maleate Oral Solution

This medicine is available in fallowing brand namesː Clistin, Palgic, Rondec, Rhinopront, Ryvent

What side effects can this medication cause?

The most common side effects of this medicine include:

• Sedation
• sleepiness
• dizziness
• disturbed coordination
• Epigastric distress
• Thickening of bronchial secretions

• Antihistamines can worsen urinary retention and glaucoma.

Less common side effects, may include:

• Urticaria, drug rash, anaphylactic shock, photosensitivity, excessive perspiration, chills, dryness of mouth, nose and throat
• Hypotension, headache, palpitations, tachycardia, extrasystoles
• Hemolytic anemia, thrombocytopenia, agranulocytosis
• fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, hysteria, neuritis, convulsions
• anorexia, nausea, vomiting, diarrhea, constipation
• Urinary frequency, difficult urination, urinary retention, early menses
• tightness of chest and wheezing, nasal stuffiness

What special precautions should I follow?

• Deaths have been reported in children less than 2 years of age who were taking antihistamines, including carbinoxamine-containing drug products, therefore, carbinoxamine maleate is contraindicated in children younger than 2 years of age.
• carbinoxamine maleate should be used with caution in patients with: increased intraocular pressure, hyperthyroidism, cardiovascular disease, hypertension.
• Antihistamines such as carbinoxamine maleate should not be used to treat lower respiratory tract symptoms, including asthma.
• Carbinoxamine maleate may cause drowsiness; alcohol, sedatives, and tranquilizers may increase the drowsiness effect. Avoid alcoholic beverages while taking this product.
• Do not take this product if you are taking sedatives or tranquilizers, without first consulting your doctor.
• Use caution when driving a motor vehicle or operating machinery.
• Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, use of carbinoxamine maleate is contraindicated in nursing mothers.
• Carbinoxamine has not been linked to instances of clinically apparent acute liver injury.

What to do in case of emergency/overdose?

Symptoms of overdosage may include:

• dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms

• Especially in infants and children, antihistamine overdosage may cause hallucinations, convulsions, or death.

Management of overdosage:

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
• The treatment of overdosage with carbinoxamine maleate is essentially symptomatic and supportive.
• Vital signs (including respiration, pulse, blood pressure, and temperature) and EKG should be monitored.
• Induction of vomiting is not recommended.
• Activated charcoal should be given and gastric lavage should be considered after ingestion of a potentially life-threatening amount of drug.
• In the presence of severe anticholinergic effects, physostigmine may be useful.
• Vasopressors may be used to treat hypotensio

Can this medicine be used in pregnancy?

• Pregnancy Category C.
• It is also not known whether carbinoxamine maleate can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity.
• Carbinoxamine maleate should be given to a pregnant woman only if clearly needed.

Can this medicine be used in children?

• Carbinoxamine maleate is contraindicated in children younger than 2 years of age.

What are the active and inactive ingredients in this medicine?

Active ingredients:

• CARBINOXAMINE MALEATE

Inactive ingredients:

• ANHYDROUS LACTOSE
• CELLULOSE, MICROCRYSTALLINE
• MAGNESIUM STEARATE
• SODIUM STARCH GLYCOLATE TYPE A POTATO

Who manufactures and distributes this medicine?

Distributed by:

• Breckenridge Pharmaceutical, Inc.
• Berlin, CT

Manufactured by:

• MIKART, LLC
• Atlanta, GA

What should I know about storage and disposal of this medication?

• Store at 20°C to 25°C (68°F to 77°F).
• Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium.

First Generation Antihistamines

• Brompheniramine
• Carbinoxamine
• Chlorcyclizine
• Chlorpheniramine
• Clemastine
• Cyclizine
• Cyproheptadine
• Dexbrompheniramine
• Dexchlorpheniramine
• Dimenhydrinate
• Diphenhydramine
• Doxylamine
• Hydroxyzine
• Meclizine
• Phenyltoloxamine
• Promethazine
• Triprolidine

Second Generation Antihistamines

• Acrivastine
• Cetirizine
• Fexofenadine
• Levocetirizine
• Loratadine
• Desloratadine

• Dailymed label info on Carbinoxamine
• FDA Carbinoxamine

Carbinoxamine Resources
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