Molindone hydrochloride

Molindone hydrochloride is an antipsychotic medication primarily used in the treatment of schizophrenia. It belongs to the class of drugs known as dopamine receptor antagonists, which work by blocking the action of dopamine, a neurotransmitter in the brain that affects thoughts and feelings.

Pharmacology

Molindone hydrochloride acts by blocking the D2 dopamine receptor, which is predominantly found in the mesolimbic pathway. This pathway is thought to be overactive in schizophrenia, and blocking the action of dopamine in this area can help to alleviate symptoms. Molindone hydrochloride also has some activity at the D1 dopamine receptor, although this is less pronounced.

Clinical Use

Molindone hydrochloride is used primarily in the treatment of schizophrenia. It can help to reduce symptoms such as hallucinations, delusions, and disorganized thinking. It may also be used in the treatment of other conditions, such as bipolar disorder, although this is less common.

Side Effects

Like all antipsychotic medications, molindone hydrochloride can have side effects. These can include drowsiness, dizziness, and dry mouth. More serious side effects can include movement disorders such as tardive dyskinesia, and changes in heart rhythm.

History

Molindone hydrochloride was first synthesized in the 1960s, and has been used in the treatment of schizophrenia since this time. It is not as commonly used as some other antipsychotic medications, such as risperidone or olanzapine, but can be a useful alternative for patients who do not respond to these drugs.

See Also

• Antipsychotic
• Schizophrenia
• Dopamine receptor antagonist
• D2 dopamine receptor
• D1 dopamine receptor
• Tardive dyskinesia