16α-Iodoestradiol

16α-Iodoestradiol is a radiopharmaceutical that is used in breast cancer research. It is a radioiodinated derivative of estradiol, an estrogen steroid hormone.

Chemistry

16α-Iodoestradiol is a steroid and a halogenated derivative of estradiol. It has a molecular weight of 432.3 g/mol and a molecular formula of C18H23IO2. The compound is solid at room temperature and is soluble in organic solvents.

Pharmacology

16α-Iodoestradiol binds to the estrogen receptor, a protein found in many tissues in the body, including the breast. By binding to the estrogen receptor, 16α-Iodoestradiol can influence the growth and development of breast cancer cells.

Medical uses

16α-Iodoestradiol is used in medical research to study the role of estrogens in breast cancer. It is used as a tracer in positron emission tomography (PET) imaging to visualize estrogen receptor-positive breast tumors.

Side effects

As a research compound, 16α-Iodoestradiol is not used in humans and therefore does not have any known side effects. However, exposure to radioiodinated compounds can potentially lead to radiation exposure.

See also

• Estradiol
• Estrogen receptor
• Breast cancer
• Radiopharmaceutical

16α-Iodoestradiol Resources
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