JWH-301
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JWH-301 is a synthetic cannabinoid that was developed by Dr. John W. Huffman and his team at Clemson University. It is part of the naphthoylindole family of compounds, which are known for their affinity to the cannabinoid receptors in the brain.
Chemical Structure and Properties[edit | edit source]
JWH-301 is characterized by its complex chemical structure, which includes a naphthoyl group attached to a tetrahydrobenzo[c]chromene moiety. The compound has a molecular formula of C24H22O3 and a molar mass of 358.43 g/mol. The stereochemistry of JWH-301 is defined by its (6aR,10aR) configuration, which is crucial for its interaction with cannabinoid receptors.
Pharmacology[edit | edit source]
JWH-301 acts as a potent agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite. The binding affinity of JWH-301 to these receptors is similar to that of other synthetic cannabinoids, making it a subject of interest in both research and forensic studies.
Legal Status[edit | edit source]
The legal status of JWH-301 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. The compound is often included in legislation targeting synthetic cannabinoids, which are frequently sold as "legal highs" or "designer drugs."
Research and Applications[edit | edit source]
JWH-301, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and the effects of cannabinoid receptor activation. However, due to its psychoactive properties and potential for abuse, its use is restricted to controlled laboratory settings.
Health Effects and Risks[edit | edit source]
The use of JWH-301, particularly in unregulated settings, poses significant health risks. These can include tachycardia, hypertension, hallucinations, and psychosis. Long-term effects are not well-documented, but the potential for addiction and adverse mental health outcomes is a concern.
Also see[edit | edit source]
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