Cefepime/enmetazobactam

Cefepime/enmetazobactam is a combination of two antibiotics, cefepime and enmetazobactam, used in the treatment of various bacterial infections. This combination is particularly effective against Gram-negative bacteria due to the synergistic effects of the two drugs.

Cefepime

Cefepime is a fourth-generation cephalosporin antibiotic. It is broad-spectrum, meaning it is effective against a wide range of bacteria. Cefepime works by inhibiting the synthesis of the bacterial cell wall, leading to cell death.

Enmetazobactam

Enmetazobactam is a beta-lactamase inhibitor. Beta-lactamase is an enzyme produced by some bacteria that provides resistance to beta-lactam antibiotics like cefepime. By inhibiting this enzyme, enmetazobactam allows cefepime to work more effectively.

Clinical Use

Cefepime/enmetazobactam is used to treat a variety of infections caused by Gram-negative bacteria, including urinary tract infections, pneumonia, and intra-abdominal infections. It is also used in the treatment of sepsis and meningitis.

Side Effects

Like all medications, cefepime/enmetazobactam can cause side effects. These may include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause more serious side effects such as seizures and Clostridium difficile-associated diarrhea.

See Also

• Cefepime
• Enmetazobactam
• Antibiotics
• Beta-lactamase inhibitor
• Gram-negative bacteria

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