Clorobiocin
Clorobiocin is a natural product and antibiotic that is derived from the Streptomyces species of bacteria. It is a member of the aminocoumarin class of antibiotics, which also includes novobiocin and coumermycin A1. Clorobiocin is known for its ability to inhibit DNA gyrase, an enzyme that is essential for DNA replication in bacteria.
History[edit | edit source]
Clorobiocin was first isolated in the 1950s from a strain of Streptomyces bacteria. The compound was initially identified for its potent antibacterial activity, and subsequent studies revealed its unique mechanism of action.
Mechanism of Action[edit | edit source]
Clorobiocin inhibits DNA gyrase by binding to the enzyme's ATP-binding site, thereby preventing the enzyme from introducing negative supercoils into DNA. This inhibitory action disrupts DNA replication and leads to cell death. Clorobiocin's mechanism of action is similar to that of other aminocoumarin antibiotics.
Clinical Use[edit | edit source]
While clorobiocin has potent antibacterial activity, it is not currently used in clinical practice. This is primarily due to the compound's poor bioavailability and the development of drug resistance by certain bacterial strains. However, clorobiocin continues to be studied for its potential use in treating multidrug-resistant bacterial infections.
Research[edit | edit source]
Research into clorobiocin has focused on understanding its mechanism of action and exploring its potential use in treating multidrug-resistant bacterial infections. Studies have also investigated the possibility of modifying the clorobiocin molecule to improve its bioavailability and overcome drug resistance.
See Also[edit | edit source]
| This article is a stub. You can help WikiMD by registering to expand it. |
 | This bacteria-related article is a stub. You can help WikiMD by expanding it. |
This DNA related article is a stub. You can help WikiMD by expanding it.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
