Piperacillin-Tazobactam

Piperacillin-Tazobactam is a combination drug used in the treatment of various bacterial infections. It is a combination of two antibiotics, piperacillin and tazobactam, which work together to inhibit the growth of bacteria.

Composition

Piperacillin is a broad-spectrum beta-lactam antibiotic that inhibits the synthesis of bacterial cell walls, leading to bacterial cell death. Tazobactam is a beta-lactamase inhibitor that prevents the breakdown of piperacillin, thereby enhancing its effectiveness.

Uses

Piperacillin-Tazobactam is used to treat a wide range of bacterial infections, including pneumonia, skin infections, urinary tract infections, and intra-abdominal infections. It is also used in the treatment of sepsis and other serious infections caused by susceptible bacteria.

Side Effects

Common side effects of Piperacillin-Tazobactam include nausea, diarrhea, and skin rash. Serious side effects may include allergic reactions, liver problems, and blood disorders.

Dosage

The dosage of Piperacillin-Tazobactam depends on the type and severity of the infection, the patient's age and weight, and the patient's kidney function. It is usually administered intravenously in a hospital setting.

Interactions

Piperacillin-Tazobactam may interact with other medications, including certain blood thinners, probenecid, and methotrexate. It is important to inform the healthcare provider of all medications being taken to avoid potential interactions.

Precautions

Patients with a history of allergy to penicillin or other beta-lactam antibiotics should not use Piperacillin-Tazobactam. It should be used with caution in patients with kidney disease, liver disease, or a history of bleeding disorders.

See Also

• Antibiotics
• Beta-lactam antibiotics
• Beta-lactamase inhibitors