B-cell maturation antigen
B-cell maturation antigen (BCMA), also known as CD269 (Cluster of Differentiation 269), is a protein that in humans is encoded by the TNFRSF17 gene. BCMA is a member of the TNF-receptor superfamily and plays a key role in B cell development, survival and function.
Structure[edit | edit source]
BCMA is a type I transmembrane protein that is predominantly expressed in plasma cells. It is a receptor for B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), two members of the TNF superfamily of cytokines. The binding of these ligands to BCMA promotes B cell survival and enhances their immune response.
Function[edit | edit source]
- BCMA is essential for the survival of long-lived plasma cells, the cells that produce antibodies in response to infection or vaccination. It does this by activating NF-kappa B and MAPK8/JNK signaling pathways, which promote cell survival and proliferation.
- BCMA also plays a role in the development of multiple myeloma, a type of cancer that forms in plasma cells. In multiple myeloma, BCMA is highly expressed on the surface of the cancer cells, making it a potential target for cancer therapy.
Clinical significance[edit | edit source]
Due to its role in B cell survival and function, BCMA is being explored as a target for the treatment of B cell-related diseases, including multiple myeloma and autoimmune diseases. Several therapies that target BCMA, including monoclonal antibody therapies and CAR T-cell therapy, are currently in clinical trials.
See also[edit | edit source]
- B-cell activating factor
- A proliferation-inducing ligand
- Multiple myeloma
- Monoclonal antibody therapy
- CAR T-cell therapy
References[edit | edit source]
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